Building protein interaction maps for Down's syndrome
نویسندگان
چکیده
منابع مشابه
Building blocks for protein interaction devices
Here, we propose a framework for the design of synthetic protein networks from modular protein-protein or protein-peptide interactions and provide a starter toolkit of protein building blocks. Our proof of concept experiments outline a general work flow for part-based protein systems engineering. We streamlined the iterative BioBrick cloning protocol and assembled 25 synthetic multidomain prote...
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Progress in high-throughput experimental techniques in the past decade has resulted in a rapid accumulation of protein-protein interaction data [27, 17, 28]. High-quality protein-protein interaction maps are useful for a deeper understanding of how proteins may together to carry out specific functions. However, high-throughput methods are known to yield a non-negligible rate of false positives,...
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The recently proposed concept of molecular connectivity maps enables researchers to integrate experimental measurements of genes, proteins, metabolites, and drug compounds under similar biological conditions. The study of these maps provides opportunities for future toxicogenomics and drug discovery applications. We developed a computational framework to build disease-specific drug-protein conn...
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Downs syndrome constitutes to be the most common chromosomal disorder. Patients with Downs's syndrome are posted for several surgeries including dental procedures and even for facial reconstruction. They are associated with several congenital anomalies in different organ system. There is also increased incidence of atlanto axial instability and risk of spinal cord injury. These children are sus...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics and Proteomics
سال: 2004
ISSN: 1473-9550,1477-4062
DOI: 10.1093/bfgp/3.2.142